Date:         Sat, 1 Sep 2001 18:43:45 +0000
Reply-To:     Mathew Thomas <thomas1131@HOTMAIL.COM>
Sender:       "SAS(r) Discussion" <SAS-L@LISTSERV.UGA.EDU>
From:         Mathew Thomas <thomas1131@HOTMAIL.COM>
Subject:      Simulation program in SAS to calculate type-I error
Content-Type: text/plain; format=flowed

Dear Statisticians,

I would like to run a simulation program in SAS to calculate the type-I
error rate in a clincial trial setup. The outcomes are proportion of
successes(Yes/No) in both the drugs(test and standard drug) and the
hypothesis tested is,

Ho: Test drug<=Standard drug
H1: Test drug> Standard drug (superiority test)

or any other hypothesis I might choose to test.

The type-I error could change if I re-estimate the original sample size
based on a different hypothesis or probably if I choose a different
hypothesis for which the rejection region is different compared to the
original hypothesis. I am kind of lost when it comes to writing a SAS
program to accomplish this task and I would sincerely appreciate if you
could give me some input.

Best Regards,
Dr. Mathew Thomas
Cleveland, Ohio

_________________________________________________________________
Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp