Date:         Thu, 6 Sep 2007 15:41:55 -0400
Reply-To:     Kevin Roland Viel <kviel@EMORY.EDU>
Sender:       "SAS(r) Discussion" <SAS-L@LISTSERV.UGA.EDU>
From:         Kevin Roland Viel <kviel@EMORY.EDU>
Subject:      Neyman-Person paradigm
Content-Type: TEXT/PLAIN; charset=US-ASCII

A collaborator asked me to respond to criticism of his grant.  He has
enrolled 74 people in a study and presented the work as preliminary to
support the grant.  The people have four levels, but he grouped them into
two.  The 2X2 p-value was 0.026.  He was able to enroll 18 more (rare
disease).  The reviewer wrote "the addition of 18 more samples is
statistically inappropriate in a Neyman-Person paradigm for analysis."

I did not read the original application.  I think the applicant failed to
stress that we would rather not group and additional patients are
necessary since we have not controlled for another exposure which is very
important.  Since this is the case, can we appropriate reply that the NP
paradigm does not apply; that additional cases must be obtained?

Thank you,

Kevin


Kevin Viel, PhD
Post-doctoral fellow
Department of Genetics
Southwest Foundation for Biomedical Research
San Antonio, TX 78227