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Date:         Mon, 17 Dec 2007 15:42:08 -0600
Reply-To:     "Paul A. Thompson" <paul@WUBIOS.WUSTL.EDU>
Sender:       "SAS(r) Discussion" <SAS-L@LISTSERV.UGA.EDU>
From:         "Paul A. Thompson" <paul@WUBIOS.WUSTL.EDU>
Subject:      Re: Performing thousands of tests automatically
Comments: To: Ron Do <rondo@HOTMAIL.COM>
In-Reply-To:  <200712172140.lBHBm2h0024591@malibu.cc.uga.edu>
Content-Type: text/plain; charset="us-ascii"

While Mary is correct in that you could do this with a macro, the COST of doing such would be unbelievably high over the BY-Variable approach. That's because there are 100,000 dataset access times to be added in. With BY-Variables, you open the dataset 1 time, and run multiple times WITHIN the procedure. With the MACRO approach, you have 100,000 extra dataset open times to be added in.

With 10 - 20 - 30 regressions, no worries, mate. With 100,000 it could be a substantial SUBSTANTIAL addition of run time.

Paul A. Thompson, Ph.D. Division of Biostatistics, Washington University School of Medicine 660 S. Euclid, St. Louis, MO 63110-1093 314-747-3793 paul@wubios.wustl.edu

-----Original Message----- From: SAS(r) Discussion [mailto:SAS-L@LISTSERV.UGA.EDU] On Behalf Of Ron Do Sent: Monday, December 17, 2007 3:40 PM To: SAS-L@LISTSERV.UGA.EDU Subject: Re: Performing thousands of tests automatically

Thanks everyone for the responses. I will try some of the suggestions and see how they work.

Mary is right, this is for a genome-wide association study using over 100,000 markers. There are some genetics programs that can handle this data, but I'm interested in applying a mixed effects model to analyse this data and hence am curious if SAS is capable of doing this.

I'll let you all know how it goes.

Cheers, Ron


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