Date:         Mon, 17 Dec 2007 15:42:08 -0600
Reply-To:     "Paul A. Thompson" <paul@WUBIOS.WUSTL.EDU>
Sender:       "SAS(r) Discussion" <SAS-L@LISTSERV.UGA.EDU>
From:         "Paul A. Thompson" <paul@WUBIOS.WUSTL.EDU>
Subject:      Re: Performing thousands of tests automatically
Comments: To: Ron Do <rondo@HOTMAIL.COM>
In-Reply-To:  <200712172140.lBHBm2h0024591@malibu.cc.uga.edu>
Content-Type: text/plain; charset="us-ascii"

While Mary is correct in that you could do this with a macro, the COST of
doing such would be unbelievably high over the BY-Variable approach.  That's
because there are 100,000 dataset access times to be added in.  With
BY-Variables, you open the dataset 1 time, and run multiple times WITHIN the
procedure.  With the MACRO approach, you have 100,000 extra dataset open
times to be added in.

With 10 - 20 - 30 regressions, no worries, mate.  With 100,000 it could be a
substantial SUBSTANTIAL addition of run time.

Paul A. Thompson, Ph.D.
Division of Biostatistics, Washington University School of Medicine
660 S. Euclid, St. Louis, MO 63110-1093
314-747-3793
paul@wubios.wustl.edu


-----Original Message-----
From: SAS(r) Discussion [mailto:SAS-L@LISTSERV.UGA.EDU] On Behalf Of Ron Do
Sent: Monday, December 17, 2007 3:40 PM
To: SAS-L@LISTSERV.UGA.EDU
Subject: Re: Performing thousands of tests automatically

Thanks everyone for the responses.  I will try some of the suggestions and
see how they work.

Mary is right, this is for a genome-wide association study using over
100,000 markers.  There are some genetics programs that can handle this
data, but I'm interested in applying a mixed effects model to analyse this
data and hence am curious if SAS is capable of doing this.

I'll let you all know how it goes.

Cheers,
Ron