Date: Fri, 17 Jul 2009 09:33:35 0400
ReplyTo: Kevin Viel <citam.sasl@GMAIL.COM>
Sender: "SAS(r) Discussion" <SASL@LISTSERV.UGA.EDU>
From: Kevin Viel <citam.sasl@GMAIL.COM>
Subject: Basics of pharma studies (EC50)
Greetings,
I have a question about the basics of timetoresponse studies for
various doses within an agent or for various agents. I will reference the
following paper:
Dosetimeresponse cumulative multinomial generalized linear model.
Chen DG. J Biopharm Stat. 2007;17(1):17385.
For what I gather, a basic shape of a response curve is assumed,
conventionally, it may be the logistic (sigmoid) curve. To frame my
thoughts, consider that I what to test whether the EC50 is statistically
different between two curves (doses or agents).
Initially, I thought that I might just add parameters to a model that
would result in different estimates of beta (consider the simple case). I
am not seeing that in the brief literature review I performed.
Unfortunately, the number of journals to which I have full text articles
is more limited than I desired and I have yet to establish access to a
large library.
How does this thought strike those in the field? It might be akin to a
random coefficient model, for instance.
My question concerning the Chen paper is why would one use probabilities
for what is essentially survival (continuous timetoevent) data? In
fact, Chen mentions a potential pitfall him or herself: namely, rates
that change over time. For instance, for days 03 the rate might be x,
for days 46 the rate might be y, and for days 7+ the rate might be z.
I would appreciate any comments or references.
Kind regards,
Kevin
