Date:         Tue, 16 Mar 1999 13:41:38 -0500
Reply-To:     Jeff Mather <Jmather@HARTHOSP.ORG>
Sender:       "SPSSX(r) Discussion" <SPSSX-L@UGA.CC.UGA.EDU>
From:         Jeff Mather <Jmather@HARTHOSP.ORG>
Subject:      general thoughts on unequal randomization
Content-Type: text/plain; charset=US-ASCII

Hi,
 
I have helped design a study with subjects randomized equally between control and experimental groups and approved as such.  The PI now wants to change the allocation of subjects where exp>control.  I'm going back to redo power estimations based on different ratios of allocation.  The increased allocation sounds reasonable from the prospective of getting as much info from the intervention as possible, yet I'm inherently against unequal allocation, but I'm having a hard time coming up with viable reasons, assuming power will not be an issue.
 
Any random thoughts on the issue, or references, would be appreciated.
thanks
Jeff
 
Jeffrey F. Mather
Research Analyst
Research Administration
Hartford Hospital
email: jmather@harthosp.org
Phone: (860) 545-2093