On another vein, I was bumped into and fell face downward into some bad 
to be
around Black Sea Urchin.  My hand went indistinctly to protect me, 
driving dozens of spines into my right hand.

I lost use of the hand - almost frozen in a shape and the body fought 
back and I won.  However, from this or other
occurrences, I had coral (that what was reported) living in my blood 
system.  Because of the coral, I could not give
blood.  I don' t know if I outgrew it.

Therefore, some wonders might not be what was needed, but hang on long 
afterwards.  Caution tread please.
Martin

On 11/7/2017 1:02 PM, [log in to unmask] wrote:
> Dear Carole,
>
> This is not really my area of expertise, although I try to keep up with developments involving conotoxins in medicine and neurobiology. The name Prialt is an acronym for "primary alternative," and specifically it is a primary alternative to morphine, because it is as effective a pain killer and is not addictive, which is a problem with morphine. However, Prialt (ziconotide) also binds so tightly to cells that the body cannot eliminate it. For that reason it is only FDA-approved for terminal patients, specifically cancer and AIDS patients. I suspect it has not been used for the granddaughter because her case is one of injury rather than an eligble disease, and there is a definite risk that relief of the pain would be accompanied by her permanently losing function of that leg.
>
> A number of researchers are attempting to modify the molecule so that it can be eliminated from the body, but I have not heard that any have been successful. However, Toto Olivera ([log in to unmask]) is certainly more aware of the latest studies than I am.
>
> I hope this is helpful and that the patient's suffering can be managed,
>
> Alan
>
> On Tue, 7 Nov 2017, John Varner wrote:
>
>> Carole,
>>
>> Prialt is the trade name of zirconotide, the first conotoxin cleared for use by the FDA.  It is already available, but is not free of side effects, and is administered via a pump to spinal fluid.  google Prialt for more info.  I work in a pain management clinic, and the docs where I work do not use it.
>>
>>
>> - John
>>
>> _____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________
>> From: Conchologists List <[log in to unmask]> on behalf of steve rosenthal <[log in to unmask]>
>> Sent: Tuesday, November 7, 2017 12:46:37 PM
>> To: [log in to unmask]
>> Subject: Re: [CONCH-L] Cone venom
>> Hi Carole, as  a general starting point:  in our industry all clinical
>> trials are now required to be listed on clinicaltrials.gov- this will
>> include those in the planning stage as well as those in progress, or
>> completed.
>>
>> if you go onto that page and search on 'conotoxin' or 'ziconotide' you
>> will find several studies listed, I am sure there are other ways to
>> search that might turn up more.
>>
>> I am sure others on here (e.g. Dr Oliveira, I hope I have spelled that
>> correctly) or Dr Kohn might have more info too.
>>
>> Steve
>>
>> On 11/7/17, Carole Marshall
>> <[log in to unmask]> wrote:
>>> Dear all,
>>>    I know there are many studies being done on the cone venom, but does anyone
>>> know of clinical trials? A long time friend has a grandaughter who is in
>>> severe pain and the hospitals cannot seem o get it under control, leg
>>> injury. If I could let her know about any trials, I will pass that
>>> information on.
>>> Hoping someone can help,
>>>    Carole Marshall
>>>
>>> ----------------------------------------------------------------------
>>> [log in to unmask] - a forum for informal discussions on molluscs
>>> To leave this list, click on the following web link:
>>> http://listserv.uga.edu/cgi-bin/wa?SUBED1=conch-l&A=1
>>> Type your email address and name in the appropriate box and
>>> click leave the list.
>>> ----------------------------------------------------------------------
>> ----------------------------------------------------------------------
>> [log in to unmask] - a forum for informal discussions on molluscs
>> To leave this list, click on the following web link:
>> http://listserv.uga.edu/cgi-bin/wa?SUBED1=conch-l&A=1
>> Type your email address and name in the appropriate box and
>> click leave the list.
>> ----------------------------------------------------------------------
>> ---------------------------------------------------------------------- [log in to unmask] - a forum for informal discussions on molluscs To leave this list, click on the following web link: http://listserv.uga.edu/cgi-bin/wa?SUBED1=conch-l&A=1 Type your email address and name in the appropriate box and click leave the list.
>> ----------------------------------------------------------------------
>>
> ----------------------------------------------------------------------
> [log in to unmask] - a forum for informal discussions on molluscs
> To leave this list, click on the following web link:
> http://listserv.uga.edu/cgi-bin/wa?SUBED1=conch-l&A=1
> Type your email address and name in the appropriate box and
> click leave the list.
> ----------------------------------------------------------------------

----------------------------------------------------------------------
[log in to unmask] - a forum for informal discussions on molluscs
To leave this list, click on the following web link:
http://listserv.uga.edu/cgi-bin/wa?SUBED1=conch-l&A=1
Type your email address and name in the appropriate box and
click leave the list.
----------------------------------------------------------------------